Fig. 6From: In vitro and in vivo single-agent efficacy of checkpoint kinase inhibition in acute lymphoblastic leukemiaCartoon drawing the rational of the study: in leukemia cells, oncogenes could lead to replication stress, activation of ATR/Chk1 pathway that in conjunction with elevated proliferation promote tolerable level of DNA damage, genomic instability, and tumor progression. Inhibition of Chk1/Chk2 could increase DNA damage leading to apoptosisBack to article page