Variables | Overall mortality | |||
---|---|---|---|---|
HR | (95 % CI) | p | ||
Conditioning | CY/TBI | (Reference) | ||
HDCA/CY/TBI | 1.50 | (1.29–1.74) | <0.01* | |
Other variables | ||||
Sex | Female | (Reference) | ||
Male | 1.00 | (0.88–1.14) | 0.96 | |
Age | ≤49 | (Reference) | ||
≥50 | 1.93 | (1.65–2.25) | <0.01* | |
PS | 0–1 | (Reference) | ||
≥2 | 2.20 | (1.74–2.80) | <0.01* | |
HCT-CI | ≤2 | (Reference) | ||
≥3 | 1.90 | (1.46–2.47) | <0.01* | |
CMV sero-status | Negative | (Reference) | ||
Positive | 1.24 | (1.04–1.48) | 0.02* | |
Diagnosis | AML | (Reference) | ||
MDS | 0.61 | (0.49–0.75) | <0.01* | |
Disease risk | Standard | (Reference) | ||
High | 2.38 | (2.10–2.71) | <0.01* | |
Days from diagnosis to HCT | ≤240 | (Reference) | ||
≥241 | 0.89 | (0.78–1.01) | 0.08 | |
Donor | Rel-BM | (Reference) | ||
Rel-PB | 1.16 | (0.96–1.40) | 0.13 | |
UR-BM | 1.11 | (0.95–1.31) | 0.20 | |
HLA mismatch | Matched | (Reference) | ||
Mismatched | 1.25 | (1.01–1.43) | <0.01* | |
Sex mismatch | Matched | (Reference) | ||
M to F | 1.04 | (0.89–1.22) | 0.60 | |
F to M | 1.16 | (0.99–1.36) | 0.07 | |
ABO mismatch | Matched | (Reference) | ||
Minor | 0.90 | (0.75–1.07) | 0.23 | |
Major | 1.11 | (0.93–1.32) | 0.23 | |
Both | 0.83 | (0.64–1.07) | 0.15 | |
GVHD prophylaxis | CyA based | (Reference) | ||
Tac based | 1.01 | (0.89–1.15) | 0.87 | |
Year of HCT | ≤2008 | (Reference) | ||
≥2009 | 0.86 | (0.75–0.99) | 0.04* |