Table 4 Most common any grade (>10 % of patients) and grade ≥3 (>1 patient) drug-related AEs
Chinese (n = 20) | Korean (n = 16) | Other (n = 7) | Overall (N = 43) | |
|---|---|---|---|---|
Any grade AE, n (%) | ||||
Skin/subcutaneous tissue disordersa | 10 (50) | 4 (25) | 7 (100) | 21 (49) |
Diarrhea | 10 (50) | 4 (25) | 3 (43) | 17 (40) |
PN NECb | 4 (20) | 3 (19) | 4 (57) | 11 (26) |
Vomiting | 4 (20) | 3 (19) | 2 (29) | 9 (21) |
Neutropenia | 3 (15) | 4 (25) | 1 (14) | 8 (19) |
Thrombocytopenia | 2 (10) | 4 (25) | 2 (29) | 8 (19) |
Decreased appetite | 5 (25) | 0 | 3 (43) | 8 (19) |
Fatigue | 2 (10) | 1 (6) | 4 (57) | 7 (16) |
Nausea | 2 (10) | 4 (25) | 1 (14) | 7 (16) |
Decreased platelet count | 3 (15) | 2 (13) | 0 | 5 (12) |
Insomnia | 3 (15) | 0 | 2 (29) | 5 (12) |
Grade ≥3 AE, n (%) | ||||
Neutropenia | 3 (15) | 4 (25) | 1 (14) | 8 (19) |
Thrombocytopenia | 1 (10) | 2 (25) | 2 (29) | 5 (12) |
Diarrhea | 0 | 4 (25) | 2 (29) | 6 (14) |
Fatigue | 1 (5) | 1 (6) | 2 (29) | 4 (9) |
Anemia | 1 (5) | 0 | 2 (29) | 3 (7) |
Hypokalemia | 1 (5) | 0 | 2 (29) | 3 (7) |