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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: Particulate cytoplasmic structures with high concentration of ubiquitin-proteasome accumulate in myeloid neoplasms

Fig. 4

PaCSs present selective immunoreactivity for chaperone molecules. a–e BM MPN cells show selective PaCS immunoreactivity for Hsp40 (a), Hsp70 (b), and Hsp90 (c, c1, and inset), although not for Bag6 (d). Autophagic vesicles remain unreactive to Hsp70 (b) and Hsp90 (c, c1), while reacting with LC3A antibody (e), where an adjacent small PaCS (arrow) does not react. mi plasma membrane invaginations in the process of severing PaCS-filled blebs from their cell of origin

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