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Table 3 Immunohistochemical staining results

From: Multiparameter analysis of homogeneously R-CHOP-treated diffuse large B cell lymphomas identifies CD5 and FOXP1 as relevant prognostic biomarkers: report of the prospective SAKK 38/07 study

 

COO

bcl2

c-myc

CD5

CD95

CD168

Cyclin E

FOXP1

pSTAT3

EBER

Evaluable cases

123

123

123

123

123

123

123

123

123

123

Mean % of stained cells ± SD

na

34 ± 38

32 ± 26

2 ± 14

32 ± 42

4 ± 9

8 ± 13

31 ± 38

19 ± 27

na

N (%) above cutoff

na

34 (28)

44 (36)

4 (3)

60 (48)

38 (31)

30 (24)

44 (36)

44 (36)

2 (1.5)

Mean % of stained cells ± SD in positive cases

na

94 ± 10

61 ± 20

72 ± 27

65 ± 38

13 ± 13

26 ± 13

79 ± 17

49 ± 26

33 ± 25

Germinal center B cell (GCB) like, N (%)

42 (34)

11 (32)a

16 (36)a

1 (25)a

22 (37)a

18 (47)a

11 (37)a

8 (18)a

17 (39)a

1 (50)a

  1. Except for FOXP1, which was of prognostic significance as an isolated marker, all other relevant proteins for cell of origin (COO) classification according to the Tally algorithm are summarized within the COO column
  2. na not applicable
  3. aGCB out of the positive cases