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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell proliferation by epigenetic silencing of KLF2

Fig. 4

Effects of down-regulation of ANRIL on tumor growth in vivo. a Tumors from mice 16 days after injection of HepG2 cells stably transfected with sh-ANRIL or empty vector. b The tumor volume was calculated every 4 days after injection of HepG2 cells stably transfected with sh-ANRIL or empty vector. Points, mean (n = 5); bars indicate s.d. c Tumor weights are represented as means of tumor weights ± s.d. d qPCR analysis of ANRIL expression in tumor tissues formed from HepG2/sh-ANRIL, HepG2/empty vector. e Tumors developed from sh-ANRIL-transfected HepG2 cells showed lower Ki-67 protein levels than tumors developed by control cells. Left: H & E staining; right: immunostaining. *P < 0.05, **P < 0.01

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