Skip to main content

Table 3 F-BAR proteins changes and potential mechanisms in diseases and pathophysiological conditions

From: F-BAR family proteins, emerging regulators for cell membrane dynamic changes—from structure to human diseases

Proteins

Changes

Disease/condition

Species

Mechanisms

PMID ID#

1. CIP4 subfamily

     

 CIP4

Embryogenesis

Drosophila

Inhibits actin nucleation associated with Diaphanous

23424199

 

Huntington’s disease

Human

Induces striatal neuron death

12604778

 

Breast tumor

Human

Suppresses Src-induced tumor cell invasion

21525036

 

Cardiac hypertrophy

Rat

Inhibits myocyte hypertrophy

23915320

 

Glucose uptake

Rat

Induces glucose uptake via GLUT4 endocytosis

19509061

 FBP17

Leukemia

Human

A fusion partner of mixed lineage leukemia

11438682

 

Bladder tumor

Human

Inhibits bladder tumor cell invasion

21421245

 

Wiskott-Aldrich syndrome

Human

Suppresses podosomes/phagocytic cup formation

19155218

2. FCHO subfamily

     

 FCHO1

Dorsoventral defects

Zebrafish

Suppresses Bmp signal transmission

22484487

3.srGAP subfamily

     

 srGAP2

Neuronal development

Mice

Suppresses neuronal development through srGAP3

23505444

 srGAP3

Neuronal development

Mice

Induces basal activity of Rac1

22820399

 

Deletion

3p syndrome

Human

Gene is deleted, mechanism not analyzed

19760623

4. PACSIN subfamily

     

 PACSIN1

Epileptic seizures

Mice

Induces hippocampal network activity

21926968

 

Huntington’s disease

Human

Induces age inappropriate synapse destablization

23852340

 PACSIN3

Embryonic defects

Zebrafish

Suppresses early formation of notochord

19997509

 

Glucose uptake

Mice

Induces glucose uptake via GLUT1 trafficking

17320047

5. PSTPIP subfamily

     

PSTPIP1

Mutation

PAPA syndrome

Human

Gene mutation alters WASP activity

21532836

PSTPIP2

Mutation

Chronic multifocal osteomyelitis

Mice

Gene mutation and IL-1β induces inflammation

16122996

6. FCHSD subfamily

     

FCHSD2

Leukemia

Human

Increases leukemia chemoresistance

22902056

7. FES/FER subfamily

     

FES/FER

Leukemia

Human

Induces growth and survival signaling in leukemia

22201778

8. NOSTRIN subfamily

     

NOSTRIN

Postnatal retinal angiogenisis

Mice

Suppresses endothelial tip cell migration

22751148

  1. F-BAR protein expression is observed in various disease and pathophysiological conditions via suggested mechanisms in human, mice, rat, zebrafish, and drosophila. Relevant publications are cited by PMID#. For other abbreviations, refer to Table 2.