Figure 5
F-BAR protein-related functions in physiological and pathophysiological conditions. The cellular functions of F-BAR proteins include endocytosis, phagocytosis, filopodium, lamellipodium, cytokinesis, adhesion, and podosome formation. These cellular functions play important roles in many physiological and pathophysiological processes, including extracellular materials uptake, antigen presentation, exosome secretion, cell migration, angiogenisis, and so on. Until now, F-BAR proteins have been found to be related with many diseases and disorders, including 1. developmental disorders, 2. neurological diseases, 3. autoinflammatory diseases, 4. cancer, 5. cardiac hypertrophy, 6. glucose uptake, and 7. renal dysfunction. Accordingly, F-BAR proteins might also be associated with cardiovascular diseases, autoimmune diseases, graft-versus-host disease, and lipid metabolism, which need to be explored in the future.