Figure 6From: Azacytidine sensitizes acute myeloid leukemia cells to arsenic trioxide by up-regulating the arsenic transporter aquaglyceroporin 9Pre-treatment with azacytidine sensitized primary AML cells to subsequent treatment with As2O3. (A) Treatment with 5′Aza resulted in significant up-regulation of HNF1A (left panel) and AQP9 (right panel) as determined by quantitative RT-PCR. (B) As2O3-mediated cytotoxicity in primary AML cells with or without 5′Aza pre-treatment as determined by MTT analysis. Sample data were normalized to the controls of each patient individually. Results represented triplicates of seven samples of primary AML cells.Back to article page