Journal of Hematology & Oncology

Table 3 Overall survival of patients with therapy-related myeloid neoplasm by univariate and multivariate analysis

From: TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemia is similar to de novo diseases

Variables	Univariate analysis			Multivariate analysis
Variables	HR	95% CI	p value	HR	95% CI	p value
Age (>60 years)	1.001	0.572–1.753	0.997	0.995	0.553–1.792	0.988
Gender (man)	0.708	0.438–1.143	0.157	0.541	0.315–0.927	0.025
ANC (<0.8 × 10⁹/L)	1.313	0.821–2.099	0.256	0.820	0.482–1.392	0.462
BM blast (≥5%)	1.633	0.941–2.836	0.081	1.580	0.853–2.924	0.145
Hemoglobin (<100 g/L)	1.946	1.153–3.286	0.013	1.711	0.950–3.081	0.073
Platelet (<50 × 10⁹/L)	2.181	1.291–3.683	0.004	2.023	1.153–3.549	0.014
Complex karyotype	2.878	1.694–4.888	<0.001	1.150	0.546–2.425	0.713
TP53 mutation	2.971	1.823–4.841	<0.001	2.958	1.476–5.929	0.002

Abbreviations: HR, hazard ratio; CI, confidence interval; ANC, absolute neutrophil count; BM, bone marrow.
p value < 0.05 is demonstrated in italics.

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ISSN: 1756-8722

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