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Figure 1 | Journal of Hematology & Oncology

Figure 1

From: Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A

Figure 1

Ideogram displaying all copy number alterations (trisomies, deletions, and gains) and sUPIDs identified by SNP array analysis of 40 diagnostic T-ALL samples. Dots and bars represents aberrations <10 and ≥10 Mb, respectively. Homozygous deletions involving 9p21.3 were categorized according to the underlying mechanism: two small (<10 Mb) deletions were graphically depicted as a red dot; two heterozygous deletions, one small <10 Mb and one large ≥10 Mb, which together results in a small homozygous deletion were shown as a red dot and a blue bar combined; and sUPID9p and a homozygous deletion were indicated as a red dot and a black bar. Homozygous deletions are placed before heterozygous deletions to the right of the chromosome, and sUPIDs are placed before gains to the left. The aberration type is depicted according to size, with the largest first.

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Journal of Hematology & Oncology

ISSN: 1756-8722

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