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Figure 9 | Journal of Hematology & Oncology

Figure 9

From: Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells

Figure 9

Schematic diagram describing the effect of oroxylin A on the inhibition of p53 degradation through the suppression of PTEN-regulated MDM2 expression. Oroxylin A enhanced cellular SIRT3 level, causing the deacetylation of PTEN and promoting its lipid phosphatase activity. The activated PTEN suppressed the transcription of MDM2, which was responsible for the degradation of p53. As a result, oroxylin A inhibited p53 degradation and the p53-related glycolytic pathway.

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Journal of Hematology & Oncology

ISSN: 1756-8722

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