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Figure 1 | Journal of Hematology & Oncology

Figure 1

From: YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway

Figure 1

Response to YM155 of primary ALL and AML patient samples. Primary patient and xenografted samples were collected as previously described [14]. (A) Samples were then incubated with increasing concentrations of YM155 (0 nM to 1 μM) and IC50 were calculated using a second-order polynomial. (Filled triangle) ALL samples without a recurring cytogenetic abnormality; (filled diamond) ALL with t(9;22); (filled circle) ALL with 11q23 rearrangement or MLL rearrangement; (filled square) ALL with <44 chromosomes or hypodiploid; (open triangle) ALL with t(1;19); (open square) ALL with t(12;21); (open circle) ALL with hyperdiploid; (grey square) total ALL; (grey triangle) total AML samples. Statistical significance of p < 0.05 by Student’s t-test between total ALL and AML samples. Samples with IC50s within the shaded area are within levels achievable in phase 1 pharmacokinetics [30]. Horizontal line denotes median IC50 of all tested samples. (B) Dose–response curves of two AML-resistant samples (red filled circle, red filled square), one ALL resistant sample (red filled triangle), one ALL intermediate sample (purple open square), and two sensitive ALL samples (black filled diamond, black filled circle). Numbers in parentheses denote patient number (Additional file 2: Table S1 and S2).

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