Figure 3

Differing HOX gene expression levels observed in PML-RARa + patients with respect to the presence of FLT3/ITD . A. HOX gene expression in the subgroup of PML-RARa+ patients with FLT3/ITD compared to the other PML-RARa+ patients. Asterisks indicated statistical significance (* ≤ 0.05, ** ≤ 0.01; additional borderline significance: p = 0.0833 for HOXA7); B. HOX gene expression levels in FLT3/ITD+ patients with PML-RARa compared to the other FLT3/ITD patients. Median expression (log2) of HOXA (left) or HOXB genes is indicated by bullets colored according to p values (Mann–Whitney tests) of differences between PML-RARa + and other groups. Color legend indicated at right. Dashed line indicating equal expression is also provided.