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Figure 2 | Journal of Hematology & Oncology

Figure 2

From: Functions of lncRNA HOTAIR in lung cancer

Figure 2

Molecular mechanisms of the tumor-promoting actions of HOTAIR. The interactions between HOTAIR and its partners are summarized. The length of each exon and positions of the interacting region for each partner are proportional to their length and positions in the principal transcript RefSeq NR_003716 of the human HOTAIR gene. The introns are not drawn proportionally to their length. A green arrow indicates positive regulation of the processes or substrates targeted by the arrow. A red arrow indicates negative regulation of the targeted processes or substrates by the arrow. A red bi-directional arrow is used to illustrate the reciprocal negative regulation between HOTAIR and miR-130a. HOTAIR’s interaction with E3 ubiquitin ligase Mex3b and its substrate Snurportin-1 is not included in the figure because the interaction is mediated through the region that overlaps with the Dzip3-Ataxin-1 interacting domain in HOTAIR. See text for details. PRC2: Polycomb Repressive Complex 2; EZH2: enhancer of zeste homolog 2; HuR: Human antigen R; LSD1: Lysine-Specific Demethylase 1.

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