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Figure 2 | Journal of Hematology & Oncology

Figure 2

From: Splicing factor 3b subunit 1 (Sf3b1) haploinsufficient mice display features of low risk Myelodysplastic syndromes with ring sideroblasts

Figure 2

Bone marrow morphology in Sf3b1+/−compared to Sf3b1+/+mice. Bone marrow (BM) cells were extracted by flushing femurs of Sf3b1+/− (n = 5) and Sf3b1+/+ (n = 5) in media supplemented with 10% fetal bovine serum. Cells (2–3 x 105) were washed and spotted on cytospin slides prior immersion in buffered Wright-Giemsa staining solution. Budding and irregular nuclei are indicated in red arrows and are also magnified in the right quadrants. This feature was also observed in slides of BM cells from Sf3b1+/− mice subjected to iron staining (Additional file 4: Figure S4). The image is presented for 1 Sf3b1+/- mouse.

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