From: Nucleo-cytoplasmic transport as a therapeutic target of cancer
Target (nuclear accumulation) | Biological effects | References |
---|---|---|
Cyclin D1 | Protein degradation, reduction of cell proliferation and increased apoptosis | |
p21 | Reduction of cell proliferation | [17] |
p27 | Reduction of cell proliferation | |
p53 | Restoration of nuclear p53 and p53-mediated response to stress | |
FOXO proteins | Activates the transcription of genes that promote cell cycle arrest, apoptosis and down-modulate Wnt/β-catenin signals | |
IκB | Attenuates constitutively activated NF-κB and causes apoptosis in cancer cells | |
BRCA1 | Resistance versus PARP inhibitors | |
Survivin | Increased apoptosis | |
Fbw7 | Degrades nuclear Notch-1 leading to decreased tumor promoting markers such as C-Myc, Cyclin-D1, Hes1 and VEGF. | [52] |
Topo IIα | Sensitization to Topoisomerase II poisons | [53] |
Nucleophosmin | Once within the nucleus it could, in principle drive Bax translocation. | |
FAS activation | Activation of intrinsic apoptosis pathway |