Figure 5From: Notch1-induced T cell leukemia can be potentiated by microenvironmental cues in the spleenA proposed model for the promoting effect of splenic microenvironment on disseminated T-ALL cells. The splenic microenvironment has high level of MIP-3β, which recruits T-ALL cells expressing a high level of CCR7. The splenic microenvironment stimulates T-ALL cells to express a higher level of MIP-3β, which further recruits T-ALL cells to the spleen. The splenic microenvironment promotes the proliferation of T-ALL cells, stimulates the expression of CCR7 and enhances the migration ability of T-ALL cells.Back to article page