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Figure 5 | Journal of Hematology & Oncology

Figure 5

From: Notch1-induced T cell leukemia can be potentiated by microenvironmental cues in the spleen

Figure 5

A proposed model for the promoting effect of splenic microenvironment on disseminated T-ALL cells. The splenic microenvironment has high level of MIP-3β, which recruits T-ALL cells expressing a high level of CCR7. The splenic microenvironment stimulates T-ALL cells to express a higher level of MIP-3β, which further recruits T-ALL cells to the spleen. The splenic microenvironment promotes the proliferation of T-ALL cells, stimulates the expression of CCR7 and enhances the migration ability of T-ALL cells.

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