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Figure 4 | Journal of Hematology & Oncology

Figure 4

From: Notch1-induced T cell leukemia can be potentiated by microenvironmental cues in the spleen

Figure 4

Impact of splenectomy on the survival of T-ALL mice. Mice were splenectomized without injection of T-ALL cells in the control group, a sham operation was conducted 24 hours after injection in the sham group, mice were splenectomized 1 week before injection in the before-I.V. group. The mice were splenectomized 24 hours after injection in the after-I.V. group. (a) Survival curves of the different mouse groups (n ≥ 7). The median survival time of the two groups undergoing splenectomy (36 and 38 days) was significantly longer than that of the sham group (26 days, p < 0.05). (b) The percentage of GFP+ leukemia cells in the peripheral blood was determined by FACS at the indicated time points. (c) Left: comparison of the normal peripheral blood cells in three leukemic mouse groups on day 23 (1 × 103 for WBC and 1 × 106 for RBC and Plts). Right: the proportion of normal BM CD3+, B220+ and Mac1+ cells in the three leukemic mouse groups on day 23. All columns represent the means ± SDs, and the statistical analysis was performed using Kaplan-Meier survival analysis and one-way ANOVA with multiple comparison test (*, P < 0.05; **, p < 0.01; ***, p < 0.001).

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