Figure 5

PBX3 expression levels associated with DNA methylation of its downstream located regulatory region. DNA methylation levels in AML patients with upregulated (up), downregulated (down) and normal levels of PBX3 expression demonstrating the impact of PBX3 methylation on expression; upregulation and downregulation was defined as a change in expression of at least one order of magnitude as well as 2-fold from healthy donors' average PBX3 expression; asterisks correspond to statistically significant changes of methylation, ***P < 0.0001, **P = 0.002.