Figure 2

Hypomethylation signature in inv(16) AML. Hypomethylation of MN1 (A), SPARC (B), ST18 (C) and DHRS3 (D) regulatory regions in inv(16) patients compared to AML M4 without inv(16), other AML subtypes and healthy controls; asterisks correspond to statistically significant changes of expression in inv(16) patients versus other groups, ***P < 0.0001.