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Figure 1 | Journal of Hematology & Oncology

Figure 1

From: CBFB-MYH11 hypomethylation signature and PBX3 differential methylation revealed by targeted bisulfite sequencing in patients with acute myeloid leukemia

Figure 1

Inv(16) methylation and expression cluster. (A) Hierarchal DNA methylation clustering of CpGs (n = 2 010 310) using the correlation as a distance measure and Ward's method (AML_1 to AML_14 - AML patients; CD34_pool - healthy control's CD34+ pool) indicating CBFB-MYH11 methylation cluster (in ellipse), other molecular abnormalities did not form clusters neither clinical characteristics did it; (B) Hierarchal gene expression clustering of altogether 8884 genes with a detection P value ≤ 0.05 in all 14 AML patients (AML_1 to AML_14) and 4 CD34+ healthy control cells confirmed inv(16) cluster (in ellipse).

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