Table 1 CTLA4-FasL or His 6 -CTLA4-FasL cytotoxic effect on different malignant and non-malignant human cell-lines
From: Highly efficient, In-vivo Fas-mediated Apoptosis of B-cell Lymphoma by Hexameric CTLA4-FasL
Cell-line type | Cell-line | Killing effect | ~EC50 | Incubation time |
|---|---|---|---|---|
Human liver cancer | Hep-G2 | Positive | 1.0 nM | 24 hours |
SK-Hep1 | Positive | 1.5 nM | 24 hours | |
Huh-7 | Negative | >>120 nM | 48 hours | |
Human liver cells (non-malignant) | FH-B | Negative | 100 nM | 24 hours |
Human kidney cancer | A498 | Positive | 1.0 nM | 24 hours |
Caki-1 | Positive | 2.0 nM | 24 hours | |
786-0 | Positive | 1.0 nM | 24 hours | |
Human kidney cells (non-malignant) | PCS-400-010 | Negative | 100 nM | 24 hours |
PCS-400-011 | Negative | 100 nM | 24 hours | |
Human lymphoma (B cells) | Raji | Positive | 0.02 nM | 24 hours |
JY | Positive | 0.04 nM | 24 hours | |
Human multiple myeloma | RPMI 8226 | Negative | >120 nM | 24 hours |
Human leukemia | HL-60 | Negative | >>120 nM | 24 hours |