Figure 2

BCL11b mRNA expression in T-ALL patients and healthy donors. A heterogeneous expression pattern was observed within the T-ALL patient samples. Samples from healthy donors had a significantly higher expression of BCL11b in CD3 positive mature T-cells than in CD34 positive progenitor cells or unselected bone marrow (BM) samples. T-ALL patients were split into BCL11b expression quartiles and patients with low or lacking expression were combined in Q1 and patients with high expression in Q2-4. Outliers (n = 4 T-ALL patients, BCL11b expression values: 6.3, 7.6, 9.7, 12.3) were omitted from the diagram but included in the statistical analysis. BM = bone marrow; *** P < 0.01.