Selective splenic artery embolization for the treatment of thrombocytopenia and hypersplenism in paroxysmal nocturnal hemoglobinuria

Table 1 Clinical and laboratory characteristics of the patients before and after SSAE procedures

Pt	Age at PNH diagnosis (year)	Spleen size in cm before SSAE	Abdominal pain prior to procedure	Representative blood counts before SSAE			% GPI-negative blood cells			SSAE procedures			Plt count post treatment	Spleen size in cm post procedure
Pt	Age at PNH diagnosis (year)	Spleen size in cm before SSAE	Abdominal pain prior to procedure	HGB g/dl	Abs Neut × 10^-3/μl	Plts × 10^-3/μl	PMNs	RBCs	Bone marrow findings	Yr of first procedure	Number of procedures	Complications	Plt count post treatment	Spleen size in cm post procedure	Follow-up, yrs
1	30 (1993)	21	Frequent attacks	10.5	1.4	42	52	15	Hypercellular; megakaryocyte aggregates	2000	3	Severe left-sided abdominal pain	123	12	12
2	18 (1990)	19	Frequent attacks	10	2.3	19	95	72	Hypocellular; megakaryocytes reduced	2005	2	Pain; large left sided pleural effusion, resolved with thoracentesis,	12	12	7*
3	27 (1989)	36	No	10.3	1.5	14	75	47	Erythroid hyperplasia; megakaryocytes adequate	2001	1	Abdominal pain	35	NA	11
4	26 (1998)	22	Occasional attacks	7.7	0.9	<10	97	55	Normocellular; megakaryocytes adequate	2009	3	Uneventful	80-100	12	3.5

*In 2009 this Patient underwent successful allogeneic stem cell transplantation from an unrelated donor.

ISSN: 1756-8722