Figure 5
From: Cardiac hypertrophy associated with myeloproliferative neoplasms in JAK2V617F transgenic mice
Reticulin fibrosis is significantly increased in hearts from JAK2V617F transgenic mice. Representative reticulin stains of heart sections from 40–45 week-old control (A and C) and JAK2V617F transgenic (B and D) mice are shown (magnification, ×40). Note that interstitial reticulin fibrosis is much more intensive in JAK2V617F transgenic mice in comparison with control mice. Data in the bar graph (E) represent quantitative measurements of interstitial reticulin staining intensity of at least 5 randomly selected segments from each of 10 control and 10 JAK2V617F transgenic mice. Error bars denote SD (n ≥50). P < 0.001.