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Figure 3 | Journal of Hematology & Oncology

Figure 3

From: Cardiac hypertrophy associated with myeloproliferative neoplasms in JAK2V617F transgenic mice

Figure 3

The size of cardiomyocytes is significantly increased in JAK2V617F transgenic mice. Representative histology of H&E-stained cardiac sections corresponding to the left ventricle free wall of hearts from 40–45 week-old control (A and C) and JAK2V617F (B and D) (magnification, ×100). A and B show myofibers running parallel to the apical-basal axis, and B and D show myofibers running circumferentially. Note that an enlarged nucleus is seen in a hypertrophic myocyte (pointed by an arrow in D). Data in the bar graph (E) represent cross-sectional area measurements of at least 20 cardiomyocytes per animal shown in A and B from 10 control and 10 JAK2V617F mice. Error bars denote SD (n ≥200). P < 0.001.

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