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Figure 7 | Journal of Hematology & Oncology

Figure 7

From: ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells

Figure 7

Efficacy of 8-Cl-Ado in breast cancer xenograft models. MCF-7 and BT474 xenografts in nude mice were established as described in Materials and Methods. Mice were treated with control PBS (0 mg/kg) or 8-Cl-Ado (100 mg/kg) three times a week for 3 weeks. MCF-7 (A) and BT-474 (B) tumor growth during 8-Cl-Ado treatment were assessed by measuring maximum tumor diameter each day of treatment. Final MCF-7 (C) and BT-474 (D) tumor volumes of tumors excised within 3 days of the final treatment. Statistical significance was determined using an unpaired t-test was used to, *P < 0.05, **P < 0.01, ***P < 0.001.

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