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Figure 1 | Journal of Hematology & Oncology

Figure 1

From: ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells

Figure 1

Effect of 8-Cl-Ado on the survival of breast cancer cells. (A) Structure of 8-Cl-Ado. (B) The effects of 8-Cl-Ado on the clonogenic growth of MCF-7 cells. Cells were treated with 10 μM 8-Cl-Ado for 3-days, washed with PBS, and cultured in fresh medium for 14-days. Colonies of >50 cells were counted under a dissecting microscope. (C) Flow cytometery analysis of annexin V and PI staining in MCF-7, hatched bars, and BT-474 cells, black bars, treated with 10 μM 8-Cl-Ado for the indicated times.

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