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Figure 2 | Journal of Hematology & Oncology

Figure 2

From: Targeting hedgehog signaling in myelofibrosis and other hematologic malignancies

Figure 2

Role of hedgehog (Hh) signaling in hematopoiesis. Preclinical studies suggest that the Hh signaling pathway may be involved in numerous stages and processes of hematopoiesis, including primitive hematopoiesis, definitive hematopoiesis—establishment, proliferation, and differentiation (lymphoid and myeloid lineages)—and maintenance of HSCs. The exact role for Hh signaling at each of these stages/processes is not clear. HSC, hematopoietic stem cell.

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