Figure 2

Genetic amplification and increased expression of EGFR protein in TMUCIH MPNST samples and its clinical significance. (A) Large-fragment amplification of chromosome 7p, including the EGFR gene. Arrow shows the location of the EGFR gene, which is amplified in 37% of the cases. (B) The EGFR/CEP7 FISH probe. (C) FISH analysis detected amplification of the EGFR gene in a representative tumor sample. Green signal represents the centromere and orange signal represents the EGFR gene. (D) EGFR protein expression in representative human MPNST tissue. (E,F) Patients whose MPNST expressed a high level of EGFR had shorter disease-free survival (E) and shorter overall survival (F).