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Figure 1 | Journal of Hematology & Oncology

Figure 1

From: RETRACTED ARTICLE: Genomic amplification and high expression of EGFR are key targetable oncogenic events in malignant peripheral nerve sheath tumor

Figure 1

Copy number alterations in 26 MPNST samples from Tianjin Medical University Cancer Institute & Hospital (TMUCIH) and 25 MPNST samples from MD Anderson Cancer Center and genetic amplifications of the EGFR signaling pathway, including those of the EGFR gene itself. (A,B) Recurrent gene copy alteration patterns in 26 MPNST from TMUCIH patients (A) and 25 MPNST from MD Anderson Cancer Center patients (B). The x-axis numbered with 1–22 denotes chromosome numbers. The y-axis shows recurrence of gains (positive axis) and losses (negative axis) for each measured locus evenly distributed in chromosomal order. Recurrence rates that exceed the threshold (dashed line) are color-coded to emphasize the locations of significantly recurrent aberrations. Red denotes significantly recurrent amplifications and green denotes significantly recurrent deletions. Gray represents nonsignificant recurrence of aberrations. (C) Aberration rates of EGFR signaling pathway genes in all 51 MPNST samples. The number on the left side is the deletion frequency (Del) of the gene, and the number on the right side is the amplification rate (Amp). Color-coding indicates the type and frequency of aberration (red amplified, green deleted). (D) Hierarchical clustering of aberrations of EGFR signaling pathway genes in all 51 MPNST samples showed a panoramic view of genetic aberrations in EGFR signal pathway. Red means amplification and green means deletion.

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