Figure 2

Amuvatinib induces apoptosis in CD138+, but not CD138– cells. (A) CD138+ and (B) CD138– cells isolated and purified from bone marrow samples of eight myeloma patients were stained with annexin V/PI and assessed by flow cytometry initially after isolation (white bars) or after 24 h of treatment with vehicle (gray bars) or 25 μM amuvatinib (black bars).