Skip to main content

Table 3 Association between individual SNPs and MDS

From: DNA repair gene variants are associated with an increased risk of myelodysplastic syndromes in a Czech population

SNP

Genotype

Controls N (%)

Cases N (%)

OR (95% CI)

p-Values

rs13240966

SLC4A2

235

173

  
 

GG

72 (30.64)

22(12.72)

1.0 (Ref)

 
 

CC

64 (27.23)

95 (57.91)

4.86 (2.74-8.62)

< 0.0001

 

CG

99 (42.13)

56 (32.37)

1.85 (1.04-3.30)

0.04

 

CC + CG

163 (69.36)

151 (87.28)

3.03 (1.79-5.13)

< 0.0001

rs2235074

ABCB1

261

188

  
 

GG

232 (88.55)

129 (68.62)

1.0 (Ref)

 
 

AA

1 (0.38)

0 (0.00)

NA

 
 

AG

28 (10.69)

59 (31.38)

3.79 (2.30-6.24)

< 0.0001

 

AA + AG

29 (11.07)

59 (31.38)

3.66 (2.23-6.00)

< 0.0001

rs20580

LIG1

264

191

  
 

CC

167 (63.26)

84 (43.98)

1.0 (Ref)

 
 

AA

20 (7.58)

33 (17.28)

3.28 (1.77-6.06)

< 0.0001

 

AC

77 (29.17)

74(38.74)

1.91 (1.26-2.89)

0.002

 

AA + AC

97 (36.74)

110 (57.59)

2.25 (1.54-3.29)

< 0.0001

rs574664

ROS1

262

189

  
 

TT

191 (72.90)

95 (50.26)

1.0 (Ref)

 
 

AA

4 (1.53)

4 (2.12)

2.01 (0.49-8.22)

0.32

 

TA

67 (25.57)

90 (47.62)

2.70 (1.81-4.03)

< 0.0001

 

AA + TA

71 (27.10)

94 (49.74)

2.66 (1.79-3.95)

< 0.0001

rs732417

STK6

257

188

  
 

GG

203 (78.99)

113 (60.11)

1.0 (Ref)

 
 

CC

0 (0.00)

2 (1.06)

NA

 
 

CG

54 (21.01)

73 (38.83)

2.43 (1.60-3.70)

< 0.0001

 

CC + CG

54 (21.01)

75 (39.89)

2.50 (1.61-3.88)

< 0.0001

rs1042838

PGR

253

189

  
 

GG

174 (68.77)

86 (45.50)

1.0 (Ref)

 
 

TT

2 (0.79)

3 (1.59)

3.04 (0.40-26.49)

0.34

 

TG

77 (30.43)

100 (52.91)

2.63 (1.74-3.97)

< 0.0001

 

TT + TG

79 (31.23)

103 (54.50)

2.64 (1.75-3.98)

< 0.0001

rs8177426

GPX3

260

171

  
 

GG

155 (59.62)

82 (47.95)

1.0 (Ref)

 
 

AA

14 (5.38)

33(19.30)

4.46 (2.16-9.32)

< 0.0001

 

AG

91 (35.00)

56 (32.75)

1.16 (0.74-1.82)

0.51

 

AA + AG

105 (40.38)

92 (53.80)

1.66 (1.10-2.47)

0.01

rs11226

RAD52

234

171

  
 

CC

(61.11)

83 (48.54)

1.0 (Ref)

 
 

TT

17 (7.26)

32 (18.71)

3.24 (1.62-6.53)

0.0002

 

TC

74 (31.62)

56 (32.75)

1.30 (0.82-2.07)

0.26

 

TT + TC

91 (38.88)

90 (52.63)

1.70 (1.15-2.54)

0.01

rs3797896

MSH3

262

191

  
 

CC

232 (88.21)

186 (97.38)

1.0 (Ref)

 
 

GG

3 (1.14)

0 (0.00)

NA

 
 

GC

27 (10.27)

5 (2.62)

0.23 (0.09-0.61)

0.001

 

GG + GC

30 (11.40)

5 (2.62)

0.21 (0.08-0.55)

0.001