All Grades, n (%) | Grade 3 or 4, n (%) | |
---|---|---|
Nonhematologic AEs occurring in ≥10% of patients | ||
Diarrhea | 14 (28.0) | 2 (4.0) |
Peripheral edema | 13 (26.0) | 0 |
Nausea | 12 (24.0) | 2 (4.0) |
Abdominal pain | 12 (24.0) | 2 (4.0) |
Fatigue | 11 (22.0) | 2 (4.0) |
Upper respiratory tract infection | 7 (14.0) | 0 |
Vomiting | 7 (14.0) | 2 (4.0) |
Hyperuricemia | 6 (12.0) | 2 (4.0) |
Muscle spasm | 6 (12.0) | 0 |
Pyrexia | 6 (12.0) | 0 |
Constipation | 5 (10.0) | 0 |
Decreased appetite | 5 (10.0) | 0 |
Dizziness | 5 (10.0) | 0 |
Pleural effusion | 5 (10.0) | 0 |
New-onset hematologic AEs | ||
Hemorrhage | 8 (16.0)* | 1 (2.0) |
Bruising (ecchymosis, contusion) | 6 (12.0) | 0 |
Laboratory values | ||
Anemia† | 29 (64.4) | 19 (42.2)‡ |
Thrombocytopenia | 32 (64.0) | 28 (56.0)§ |