Fibroblast growth factor-2 (FGF2) and syndecan-1 (SDC1) are potential biomarkers for putative circulating CD15+/CD30+ cells in poor outcome Hodgkin lymphoma patients

Table 3 Characteristics of HL cell lines

Cell line	Clinical characteristic	Anatomic site of primary cell
DEV	relapse	Pleural fluid
HDLM2	n/a	Pleural fluid
HD-MY-Z	refractory	Bone marrow
KM-H2	relapse	Pleural fluid
L1236	refractory/relapse	Peripheral blood
L428	refractory	Pleural fluid
L540	n/a	Bone marrow
L591	n/a	Pleural fluid
SUP-HD1	relapse	Pleural fluid
U-H01	refractory	Pleural fluid

A review of the literature showed that all established HL cell lines were derived from primary malignant CD30+ cells isolated from extra-nodal sites: pleural fluid, bone marrow, and peripheral blood. No cell lines to date have been raised from primary HRS cells isolated from lymph nodes.

ISSN: 1756-8722