Table 1 Selected histone deacetylase inhibitors
From: Epigenetic changes: a common theme in acute myelogenous leukemogenesis
Name | Chemical class | Formula | Target | Number AML trials | |
|---|---|---|---|---|---|
Open/Total | + Azacytidine open/Total | ||||
Phenylbutyrate | Short fatty acid chain |
| Pan-inhibitor | 0/6 | 0 |
Valproic acid | Short fatty acid chain |
| ClassI/IIa | 5/14 | 1/7 |
Vorinostat (SAHA) | Hydroxamic acid |
| Pan-inhibitor | 8/25 | 2/4 |
Belinostat (PXD101) | Hydroxamic acid |
| Pan-inhibitor | 1/4 | 0/1 |
Panobinostat (LBH589) | Hydroxamic acid |
| Pan-inhibitor | 7/11 | 2/3 |
Trichostatin A | Hydroxamic acid |
| Pan-inhibitor | 0 | 0 |
Givinostat (ITF2375) | Hydroxamic acid |
| Pan-inhibitor | 0 | 0 |
Mocetinostat (MGCD0103) | Benzamide |
| Class I/IV | 0/3 | 0/1 |
Entinostat (MS275-SNDX275) | Benzamide |
| Class I | 2/7 | 1/3 |
Romidepsin (Depsipeptide) | Cyclic tetrapeptide |
| Class I | 0/5 | 0/1 |
Trapoxin B | Cyclic tetrapeptide |
| Class I/IIa | 0 | 0 |
