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Figure 8 | Journal of Hematology & Oncology

Figure 8

From: Immunoglobulin E induces VEGF production in mast cells and potentiates their pro-tumorigenic actions through a Fyn kinase-dependent mechanism

Figure 8

IgE improves the pro-angiogenic properties of MC through a Fyn kinase-dependent mechanism. Circulating IgE binds to the FcϵRI receptor on MC surface inducing the secretion of pro-angiogenic factors able to promote tumor angiogenesis and contribute to melanoma tumor growth. Fyn kinase is an important element on IgE-dependent production of pro-angiogenic factors in MC.

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Journal of Hematology & Oncology

ISSN: 1756-8722

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