From: Biomarkers for determining the prognosis in chronic myelogenous leukemia
 | Sokal | Hasford (EURO) | EUTOS |
---|---|---|---|
Year introduced | 1984 | 1998 | 2011 |
Predominant treatment modality | Conventional chemotherapy | Interferon-α–based regimens | Imatinib |
Factors | •Age | •Age | •Spleen size |
•Spleen size | •Spleen size | •Basophil count | |
•Platelet count | •Platelet count | ||
•Percentage of blasts | •Percentage of blasts | ||
•Percentage of basophils | |||
•Percentage of eosinophils | |||
Calculation of score | Exp 0.0116 (age – 43) + 0 .0345 (spleen size [cm below costal margin] – 7.5 cm) + 0.188 [(platelet count/700)2 – 0.563] + 0.0887 (% blasts in blood – 2.1) | (0.6666 × age [0 when age <50 years; 1, otherwise] + 0.0420 × spleen size [cm below costal margin] + 0.0584 × blasts [%] + 0.0413 × eosinophils [%] + 0.2039 × basophils [0 when basophils <3%; 1, otherwise] + 1.0956 × platelet count [0 when platelets <1500 × 109/L; 1, otherwise]) × 1000 | 7 × basophils + 4 × spleen size |
Risk groupsa | •High: score > 1.2 | •High: score >1480 | •High: score > 87 |
•Intermediate: score 0.8-1.2 | •Intermediate: score >780 and ≤1480 | •Low: score ≤ 87 | |
•Low: score < 0.8 | •Low: score ≤ 780 |