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Table 2 Sokal, Hasford, and EUTOS Systems[13–15]

From: Biomarkers for determining the prognosis in chronic myelogenous leukemia

 

Sokal

Hasford (EURO)

EUTOS

Year introduced

1984

1998

2011

Predominant treatment modality

Conventional chemotherapy

Interferon-α–based regimens

Imatinib

Factors

•Age

•Age

•Spleen size

•Spleen size

•Spleen size

•Basophil count

•Platelet count

•Platelet count

•Percentage of blasts

•Percentage of blasts

•Percentage of basophils

•Percentage of eosinophils

Calculation of score

Exp 0.0116 (age – 43) + 0 .0345 (spleen size [cm below costal margin] – 7.5 cm) + 0.188 [(platelet count/700)2 – 0.563] + 0.0887 (% blasts in blood – 2.1)

(0.6666 × age [0 when age <50 years; 1, otherwise] + 0.0420 × spleen size [cm below costal margin] + 0.0584 × blasts [%] + 0.0413 × eosinophils [%] + 0.2039 × basophils [0 when basophils <3%; 1, otherwise] + 1.0956 × platelet count [0 when platelets <1500 × 109/L; 1, otherwise]) × 1000

7 × basophils + 4 × spleen size

Risk groupsa

•High: score > 1.2

•High: score >1480

•High: score > 87

•Intermediate: score 0.8-1.2

•Intermediate: score >780 and ≤1480

•Low: score ≤ 87

•Low: score < 0.8

•Low: score ≤ 780

  1. aAn intermediate risk category is not defined for EUTOS.