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Figure 6 | Journal of Hematology & Oncology

Figure 6

From: Histone deacetylase inhibitor potentiated the ability of MTOR inhibitor to induce autophagic cell death in Burkitt leukemia/lymphoma

Figure 6

Valproic acid synergized with temsirolimus in a murine xenograft Burkitt leukemia/lymphoma (BL) model. (A) Valproic acid (VPA) combined with temsirolimus (TEM) significantly inhibited BL xenograft tumor growth. (B) Immunohistochemical study showed that CDKN1A activation is more obvious in VPA-treated groups, and MYC inhibition is most significant in the combination group. (C) Ultrastructural study showed increased numbers of autophagic cells in the combination group. (D and E) Decreased proliferative index Ki67 was identified, (D) while TUNEL staining was negative in the combination group. (E) The tissue section of the same murine xenograft model co-treated with bortezomib (BOR) and suberoylanilide hydroxamic acid (SAHA) was referred as a positive control.

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