Figure 3

Valproic acid combined with temsirolimus inhibited primary Burkitt leukemia/lymphoma (BL) cell growth without affecting the proliferation capacity of normal hematopoietic progenitor cells. Valproic acid (VPA, 0.5 mM) combined with temsirolimus (TEM, 1 nM) inhibited the growth of primary BL cells (A), whereas the proliferation of normal progenitor cells was not affected by VPA (up to 8 mM) and TEM (up to 0.5 μM) (B).