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Figure 1 | Journal of Hematology & Oncology

Figure 1

From: Histone deacetylase inhibitor potentiated the ability of MTOR inhibitor to induce autophagic cell death in Burkitt leukemia/lymphoma

Figure 1

Valproic acid combined with temsirolimus inhibited Burkitt leukemia/lymphoma (BL) cell growth. (A) In BL cell line Namalwa and Raji, co-treatment of valproic acid (VPA) with temsirolimus (TEM) induced significant growth inhibition, comparing with each agent alone. (B) Isobolographic curve showed that the data points lie to the left of the envelope of additivity (gray area), indicating that the combination is synergistic in BL cell lines Namalwa, Raji, Daudi and Ramos. (C-E) When VPA (0.5mM) was combined with TEM (1 nM), the percentages of G0/G1 phase cells were significantly increased (C), without obvious change of cell apoptosis (D) or differentiation (E). ***P<0.001 and **P<0.01 comparing with the combination group.

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