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Table 3 Correlation of DWI and MRP parameters with PFS in HCC and tumor thrombus

From: Magnetic resonance imaging biomarkers in hepatocellular carcinoma: association with response and circulating biomarkers after sunitinib therapy

  

Baseline

 

Percent changes (%)

 

Parameters

PFS>6 months

PFS6 ≤ months

P value

PFS>6 months

PFS6 ≤ months

P value

(Median, Range)

(Median, Range)

(Median, Range)

(Median, Range)

RECIST

      

HCC (cm)

10.00, 5.20 ~ 14.00

10.00, 2.30 ~ 17.00

0.682

3.57, –36.54 ~ 35.00

7.60, –43.48 ~ 58.23

0.875

Tumor thrombus(mm)

23.87, 22.14 ~ 28.50

30.79, 24.65 ~ 38.34

0.114

−15.23, –25.62 ~ 10.26

9.72, –28.52 ~ 42.92

0.019

mRECIST

      

HCC (cm)

10.70, 2.15 ~ 19.56

9.66, 2.24 ~ 15.86

0.207

−0.88, –11.16 ~ 11.00

1.89, –19.84 ~ 15.86

0.517

DWI

      

HCC

ADC (×10 -3 mm 2 /s)

0.83, 0.65 ~ 1.01

0.90, 0.69 ~ 1.09

0.570

19.48, –12.84 ~ 40.00

22.22, –8.99 ~ 51.72

0.825

Tumor thrombus

ADC (×10 -3 mm 2 /s)

0.74, 0.60 ~ 1.03

0.93, 0.79 ~ 1.14

0.085

10.38, –13.28 ~ 39.94

21.11, –62.33 ~ 114.23

0.315

MRP

      

HCC

Ktrans (min −1 )

2.80, 1.00 ~ 4.81

1.70, 0.90 ~ 4.1

0.043

−52.27, –83.37 ~ −7.00

−41.25, –75.61 ~ -6.00

0.467

 

Kep (min −1 )

3.01, 1.00 ~ 41.75

2.79, 1.27 ~ 4.36

0.100

−49.58, – 96.32 ~ 28.04

−46.33, –77.05 ~ -1.67

0.914

 

EVF

0.93, 0.57 ~ 1.00

0.88, 0.34 ~ 1.00

0.590

−8.77, –47.50 ~ 20.55

–2.38, –30.12 ~ 61.76

0.022

Tumor thrombus

Ktrans (min −1 )

1.65, 0.93 ~ 2.33

1.98, 1.05 ~ 2.99

0.374

−58.48, –72.65 ~ −47.35

−23.11, –63.23 ~ 24.14

0.005

 

Kep (min −1 )

2.43, 1.32 ~ 4.03

1.95, 1.05 ~ 2.76

0.220

−42.53, –67.42 ~ −23.64

−34.58, –80.01 ~ 18.98

0.135

 

EVF

0.78, 0.70 ~ 0.92

0.88, 0.82 ~ 0.98

0.120

−11.30, –31.95 ~ 0.56

−22.43, –38.12 ~ −19.75

0.331

  1. Abbreviations: Ktrans Transfer constant; Kep Rate constant; EVF Extracellular volume fraction; ADC Apparent diffusion coefficient.