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Table 1 Tumor and tumor thrombus size, DWI and MRP parameters at baseline and post antiangiogenic treatment

From: Magnetic resonance imaging biomarkers in hepatocellular carcinoma: association with response and circulating biomarkers after sunitinib therapy

Parameters

Baseline (Median, Range)

Post-sunitinib (Median, Range)

P value

SIZE

   

RECIST

10.00, 2.30 ~ 17.00

11.10, 1.30 ~ 25.00

0.197

m RECIST

9.94, 2.15 ~ 19.56

10.11, 2.11 ~ 18.55

0.963

Tumor thrombus(mm)

28.67, 21.87 ~ 36.63

29.81, 21.98 ~ 37.73

0.365

DWI

   

HCC

ADC (×10 -3 mm 2 /s)

0.88, 0.58 ~ 1.09

0.98, 0.75 ~ 1.21

<0.0001

Tumor thrombus

ADC (×10 -3 mm 2 /s)

0.89, 0.60 ~ 1.14

1.02, 0.78 ~ 1.26

0.035

MRP

   

HCC

Ktrans (min −1 )

2.15, 0.90 ~ 4.81

0.94, 0.57 ~ 2.30

<0.0001

Kep (min −1 )

2.61, 1.00 ~ 41.75

1.22, 0.66 ~ 2.64

<0.0001

EVF

0.926, 0.34 ~ 1.00

0.81, 0.65 ~ 0.97

0.079

Tumor thrombus

Ktrans (min −1 )

1.89, 0.93 ~ 2.99

0.99, 0.37 ~ 1.61

0.110

Kep (min −1 )

2.37, 1.05 ~ 4.03

1.49, 0.61 ~ 2.37

0.190

EVF

0.83, 0.70 ~ 0.98

0.66, 0.56 ~ 0.77

0.055

  1. Abbreviations: Ktrans Transfer constant; Kep Rate constant; EVF Extracellular volume fraction; ADC Apparent diffusion coefficient.