Figure 2From: Signal transduction inhibitors in treatment of myelodysplastic syndromesModel for pathogenesis of MDS. A mutation or epigenetic alteration in hematopoietic stem cells (HSC), leads to generation of pro-inflammatory milieu in marrow microenvironment that can result in apoptotic cell death of normal HSCs. Inhibition of myelo-suppressive cytokine signaling cascades can stimulate hematopoietic activity in HSCs.Back to article page