Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology

Table 1 CTAP III biological functions

Regulation of hematopoiesis	Inhibition of megakaryocytopoiesis [19]
Immunoregulatory activity	Histamine release by basophils [37]
Immunoregulatory activity	Precursor of NAP-2 [31]
Angiogenesis	Chemotaxis of EC in vitro[5]
Connective tissue cells metabolism	Mitogenesis [34]
	Glycolysis [34]
	Hyaluronic acid and GAGs synthesis [22, 34]
	Prostaglandin E₂ secretion [22]
	Plasminogen activator synthesis [35]
Others	Stimulation of glucose transport [38]
Others	Transcellular mediator of the cellular sphingomyelin import [39]
	Heparanase activity [40]

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