Table 1 Baseline characteristics and medical history
Prasugrel 5 mg n = 41* | Placebo n = 21 | p value | |
|---|---|---|---|
Age (mean, years) | 32.9 | 31.5 | 0.553 |
Female, n (%) | 21 (51.2) | 9 (42.9) | 0.598 |
Body Weight (mean, kg) | 78.3 | 68.6 | 0.021 |
Hydroxyurea | 18 | 9 | |
Sickle-cell Genotype, n (%) | >0.999 | ||
Hb S/ β0 thalassemia | 2 (5.0) | 1 (4.8) | |
Hb S/ βthalassemia | 4 (10.0) | 2 (9.5) | |
Hb SC | 10 (25.0) | 5 (23.8) | |
Hb SS | 24 (60.0) | 13 (61.9) | |
Pain Intensity | 0.473 | ||
Mean | 1.8 | 2.4 | |
Minimum | 0.0 | 0.0 | |
Median | 0.0 | 2.0 | |
Maximum | 9.0 | 7.0 | |
Medical History, n (%) | |||
Vaso-occlusive crisis | 25 (61.0) | 12 (57.1) | |
Acute chest syndrome | 9 (22.0) | 2 (9.5) | |
Hepatic sequestration | 0 | 1 (4.8) | |
Splenectomy | 7 (17.1) | 5 (23.8) | |
Systemic hypertension | 11 (26.8) | 2 (9.5) | |
Pulmonary hypertension | 7 (17.1) | 2 (9.5) | |
Renal failure | 1 (2.4) | 0 | |
Hepatic disease† | 1 (2.4) | 0 | |
Renal insufficiency | 0 | 1 (4.8) | |
Laboratory Values, mean (SD) | |||
Hemoglobin (g/L) | 10.4 (1.8) | 9.8 (2.0) | 0.297 |
White Blood Cells (x109/L) | 8.2 (3.4) | 8.3 (2.7) | 0.929 |
Platelets (x109/L) | 310.6 (180.4) | 340.5 (117.5) | 0.561 |