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Figure 4 | Journal of Hematology & Oncology

Figure 4

From: Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice

Figure 4

Delayed hematological recovery and reduced donor cell contribution in secondary transplant mice receiving BM cells from Pim TKO primary transplant recipients. BM cells were harvested from primary transplant recipients at 4 months post transplantation and injected into lethally irradiated female FVB recipients (1 × 107/mouse). (A) Lower peripheral white blood cell counts in Pim TKO secondary transplant recipient mice. Peripheral white blood cell count in the secondary transplant recipient mice was measured at 3 months post transplant (n=6 for WT; n=3 for Pim TKO mice, *p < 0.05). (B) Reduced donor cell engraftment in the BM of Pim TKO secondary transplant recipient mice. The secondary transplant recipient mice were sacrificed at 4 months post transplant and BM cells were harvested and analyzed for male donor cell engraftment (*p < 0.05).

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