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Figure 2 | Journal of Hematology & Oncology

Figure 2

From: Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy

Figure 2

Expression pattern of Muc1 during the progression of pancreatic cancer in KrasG12Dmouse model. (A) Muc1 mRNA expression was determined by quantitative real time PCR. (B, C, D, E, F, and G) Muc1 protein expression during the progression of pancreatic cancer in KrasG12D mouse model was analyzed by IHC. The formalin fixed pancreatic tissue collected during mouse PC progression (10 weeks to 50 weeks) were paraffin embedded and 4 μm tissue sections were cut and stained with anti-Muc1 antibody. Light microscopic pictures (200x) are shown. (H) Composite scores of pancreatic tissues of KrasG12D;Pdx1-Cre mice stained with anti-Muc1 antibody. (I) Normal pancreas isolated from 50 week old mice showing expression of Muc1 in normal ducts. (J, K, L) Muc1, expression in the metastatic lesions involving liver, small intestines and lungs, respectively isolated from 50 week KrasG12D mice.

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