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Table 1 Characteristics of lymphoma patient samples

From: HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (cis-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas

Patient#

AGE

SEX

RACE

TYPE OF LYMPHOMA

CYTOGENETICS/KARYOTYPE

p53 status Exons 5-9 (cDNA)

1

62

M

Caucasian

MZL

Normal/46,XY [23]

wt

2

76

M

Caucasian

SLL/CLL

84.5%-trisomy 12

wt

15.5%- deletion of 17p

11%-loss of lgH locus

3

86

M

Caucasian

MZL

Normal/46, XY [23]

wt

4

71

F

Caucasian

SLL/CLL

67.5%-trisomy 12

wt

5

64

F

African-American

SLL/CLL

86.5%-deleted 13q

wt

6

72

M

Caucasian

MZL

45%-t(2;7)(p12;q21-22)

wt

7

64

F

Caucasian

SLL/CLL

54.5%- deleted 13q

wt

8

81

F

Caucasian

SLL/CLL

58.5%- deleted 13q

wt

9

69

F

Caucasian

SLL/CLL

51%- deleted 13q

mt

9%- deleted 17p

(Lys132Arg)

10

62

M

Caucasian

SLL/CLL

23.5%- deleted 13q

wt

26%-31gH copies

11

69

F

Caucasian

SLL/CLL

72%- deleted 13q

wt